The 30-share barometer fell by 90.36 points, or 0.44 per cent, to 20,423.49. The index had gained 15.60 points in the previous session.
Stocks of IT, consumer durables, realty, capital goods and oil and gas sectors led the fall.
Similarly, the wide-based National Stock Exchange index Nifty declined by 26.10 points, or 0.43 per cent, to 6,063.40.
Brokers said trading sentiment dampened largely in line with a weak trend in the Asian region following another global sell-off caused by anxieties over emerging markets and further disappointing manufacturing data from China.
In the Asian region, the Japan’s Nikkei down 1.24 per cent in early trade today, while Hong Kong markets closed for public holiday.
The US Dow Jones Industrial Average ended 0.94 per cent lower in Friday’s trade.