The 30-share barometer, which had gained over 310 points in the previous four sessions, lost 82.20 points, or 0.38 per cent, to 21,291.46, with banking, metal, healthcare and realty sector stocks leading the fall.
Similarly, the wide-based National Stock Exchange index Nifty declined 27.15 points, or 0.43 per cent, to 6,318.50.
Brokers said besides profit-booking by funds and retail investors at record level, a weak trend on other Asian bourses tracking overnight falls on Wall Street mainly influenced the sentiment here.
In the Asian region, Hong Kong’s Hang Seng fell by 0.93 per cent while Japan’s Nikkei by 1.54 per cent in early trade today.
The US Dow Jones Industrial Average ended lower by 1.07 per cent in yesterday’s trade.