She made her acting debut in the Telugu movie Sweetheart which did not do well at box office. Later she acted in many Kannada films including blockbuster movies Pancharangi, Veera Bahu, Krishnan Marriage Story.
Nidhi was nominated to South Filmfare awards for her performances in the films Pancharangi and Krishnan Marriage Story.
She got nationwide attention when she appeared in bikini for CCL 2012 calendar.
Nidhi Subbaiah made her bollywood debut in the movie Oh My God as a TV journalist which did not bring much fame to her. She is now keeping all hopes on Ajab Gazabb Love, a remake of Telugu movie Seema Tapakai to establish herself in bollywood.